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Selected Publications
Li J#., Choi E.#*., Yu H.*, Bai XC.* (2019). Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat. Commun. 10, 4567 (#Co-first author, *Co-corresponding author)
Uchikawa E.#, Choi E.#*, Shang G., Yu H.*, Bai XC.* (2019). Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex. eLife 8, e48630. (#Co-first author, *Co-corresponding author)
Choi E., Kikuchi S., Gao H., Brodzik K., Nassour I., Yopp A., Singal A., Zhu H., and Yu H. (2019). Mitotic regulators and the SHP2-MAPK pathway promote insulin receptor endocytosis and feedback regulation of insulin signaling. Nat. Commun. 10, 1473.
Choi E. and Yu H. (2018). Spindle checkpoint regulators in insulin signaling. Front. Cell Dev. Biol. 6:161.
Kim J., Hu Z., Cai L., Li K., Choi E., Faubert B., Bezwada D., Rodriguez-Canales J., Villalobos P., Lin YF., Ni M., Huffman K., Girard L., Byers L., Kacmaz K., Pna C., Heymach J., Wauters E., Vansteenkiste J., Castrillon D., Chen B., Wistuba I., Lambrechts D., Xu J., Minna J., and DeBerardinis R. (2017). CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature 546 (7656): 168-72.
Choi E., Zhang X., Xing C., and Yu H. (2016). Mitotic checkpoint regulators control insulin signaling and metabolic homeostasis. Cell 166 (3): 567-81.
Choi E. and Yu H. (2015). Phosphorylation propels p31comet for mitotic exit. Cell Cycle 14 (13) 1997-8.
Park I., Lee HO., Choi E., Lee Y-K., Kwon M-S., Min J., Park P-G., Lee S., Kong Y-Y., Gong G., and Lee H. (2013). Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation. J. Cell Biol. 202 (2): 295-309.
Choi E#., Park P-G#., Lee HO#., Lee Y-K., Kang GH., Lee JW., Han W., Lee HC., Noh D-Y., Lekomtsev S., Gong GY., and Lee H. (2012). BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation. Dev. Cell 22:295-308. (#Co-first author)
Choi E., Choe H., Min J., Choi J-Y., Kim J., and Lee H. (2009). BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing in mitosis. EMBO J. 28: 2077-2089.
Lee Y., Choi E., Park P-G., Kim M. A., Park N-H, and Lee H. (2009). BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers. Brit. J. Cancer 101: 504-510.
Choi E. and Lee H. (2008). Chromosome damage induces BubR1 activation and prometaphase arrest. FEBS Letters 582:1700-1706.
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